A photo posted by the Alachua County Fire Rescue shows a tractor-trailer in flames with a vehicle under its left side.
The Florida Highway Patrol said two tractor-trailers, a passenger van and a midsize sedan were involved in the crash.
The accident happened Thursday afternoon at mile marker 393 on I-75 southbound.
Some of the patients transported from the scene have critical injuries, according to the fire and medical service.
The vehicle fire was put out by crews arriving on scene.
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