Of these, 62 have been confirmed by the CDC in 22 states, and the remainder continue to be investigated.
Acute flaccid myelitis, also called AFM, is a rare but serious condition that affects the nervous system -- specifically, the area of the spinal cord called gray matter. It affects fewer than one in a million people each year across the country, the CDC estimates.
The number of patients under investigation is up from 127 patients a week ago, though no new confirmed cases have been reported.
The average age of patients confirmed to have the condition is just 4 years old, and more than 90% of cases overall occur in children 18 and younger, according to Dr. Nancy Messonnier, director of the agency's National Center for Immunization and Respiratory Diseases.
"CDC has been actively investigating AFM, testing specimens and monitoring disease since 2014, when we first saw an increase in cases," Messonnier told reporters last week. "Most AFM cases occur in the late summer and fall," but no geographic clustering has been found and there is no other "unifying factor to explain the peaks," which seem to occur every other year, she added.
The CDC received information on 33 confirmed cases of AFM in 2017, 149 cases in 2016, 22 cases in 2015, and 120 cases in the latter part of 2014.
"There is a lot we don't know about AFM," including the cause in a majority of cases, Messonnier said. While potential causes may include certain viruses, environmental toxins and genetic disorders, the CDC says, "AFM can be difficult to diagnose because it shares many of the same symptoms as other neurologic diseases."
It is also unclear who could be at higher risk of developing AFM, Messonnier said. The CDC does not fully understand long-term consequences or why some patients recover quickly while others continue to experience paralysis and weakness.
The CDC urges parents to be aware of this illness and to seek medical care right away if family members develop sudden weakness or loss of muscle tone in the arms or legs.
"This is a mystery so far, and we haven't solved it yet, so we have to be thinking broadly," Messonnier said.
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